EmbryoScope+ and EmbryoScope™ – System of embryo monitoring

We are one of the few clinics in Europe that can offer customers embryo cultivation in EmbryoScope+ and EmbryoScopeTM.

It is the most advanced embryo incubator available on the IVF market today. It is an excellent tool to find the best embryos for transfer and maximize the chances of a successful pregnancy.

EmbryoScope+ and EmbryoScopeTM are systems with built-in camera for morphokinetic evaluation of embryo quality.

EmbryoScope+
Is the system with the largest capacity of all time-lapse systems. The advantage of this incubator is that embryos from 15 patients can be examined simultaneously, and we can monitor up to 16 embryos for each.

EmbryoScopeTM
Provides watching of 72 embryos at once – 6 petri dish with 12 embryos in each dish (one dish for one patient. Development of embryo is a very dynamic process. The incubator allows us to record a picture of each embryo every 20 minutes.
One of the key aspects in the treatment of infertility by artificial insemination is the selection of embryos with the highest probability of implantation. Embryo development is a dynamic process, and in normal cultivation in common incubators it is not possible to monitor morphological changes over time.

EmbryoScope+ and EmbryoScope™ allow the evaluation of the following parameters, as:

• The exact determination of time when the embryo started to differentiate as well as time of further embryo differentiation
• Synchronization of all time periods of embryo differentiations
• Course of fragmentation
• Forming the nuclei after embryo differentiation
• Non-stop watching of all embryos in course of their cultivation
• Minimal manipulation with embryos

The observation of the course of embryo division offers new insights into differences in embryo division parameters between implanted and non-implanted embryos. EmbryoScope+ and EmbryoScopeTM enable fast and accurate regulation of CO2 concentration, which is adjusted in less than 3 minutes after chamber closure (conventional incubators adjust internal temperature and CO2 concentration within 1 hour after closure).

Another advantage is their unique temperature control (the temperature practically does not change (<0.2 ºC) until the chamber is opened). They use uninterrupted circulation and cleaning of air reserves, which are renewed every 10 minutes. The air is purified using a Whatman TM filter, which works on the principle of activated carbon and HEPA filters, removing volatile organic compounds and collecting 99.97% of all particles larger than 0.3 μm . They allow dry incubation without water, eliminating potential condensation problems.

A high quality Hoffmann modulation contrast microscope allows the observation of important morphological parameters of the embryo. To avoid exposure of the embryo to strong light, the special contrast objective “Leica 20 x 0.40 LWD Hoffman Modulation” was developed, which uses red light with a wavelength of 635 nm. The embryo is exposed to the light for less than 0.5 seconds at each exposure.

The morphokinetic approach, as a non-invasive method for quality evaluation of embryos, offers new possibilities to increase the successful treatment of infertile couples. It is based on observational methods with a focus on morphology, but also on the dynamic development of the embryo, without compromising cultivation conditions.